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 Migraine…? | Migraine Advisor



Is there any effective medicine for Migraine?

Chosen Answer:

Imitrex works well to treat migraines or a Verapamil is a good drug to help prevent migraines in the first place.
by: Emily B
on: 24th October 07

13 Comments to “Migraine…?”

  1. dot&carryone. Says:

    Feverfew for Migraine Prophylaxis
    Clinical bottom line: Overall, these studies suggest that feverfew may be beneficial for the prevention of migraine attacks. However, the effectiveness has not been established beyond reasonable doubt. More data is needed to determine which dose and formulation should be prescribed, and how effective it is. Future trials should measure clinically relevant outcomes in accordance with International Headache Society (IHS) criteria.


    Feverfew (Tanacetum parthenemium L) is a popular herbal remedy recommended for the prevention of migraine. The pharmacological properties of feverfew have been extensively investigated but remain unclear.

    Systematic review
    Vogler BK, Pittler MH and Ernst E. Feverfew as a preventive treatment for migraine: a systematic review. Cephalalgia. 1998; 18:704-708

    Date review completed: April 1998

    Number of trials included: 5

    Number of patients: 196

    Control group: placebo

    Main outcomes: headache severity and frequency, nausea and vomiting, photophobia

    Inclusion criteria were randomised, double-blind, placebo-controlled trials of feverfew mono-preparations taken for migraine prophylaxis. No restriction to language of publication.

    Reviewers conducted extensive searches of all main databases and reference lists of retrieved reports, and contacted manufacturers of feverfew preparations. Trials were scored for methodological quality using the Oxford scale (Jadad et al., 1996). Reviewers provided a descriptive summary of included trials, as pooling of data for meta-analysis was not possible.

    Five trials were found, one in abstract form that measured serotonin uptake and platelet activity and is not discussed further here. Four randomised, double-blind, placebo-controlled trials were found reporting on clinical outcomes. All trials scored at least three of five points on the quality scale. Trials varied with respect to dosing schedules and formulations of feverfew, and outcome measures. Only one trial used IHS criteria for migraine definition, diagnostic criteria were unclear in two of the other trials. Three trials were of crossover and one of parallel design. Reviewers did not state if there were any carry-over effects in the crossover studies. One trial had less than ten patients per treatment group. Overall three trials reported results in favour of feverfew over placebo and one found no difference.

    One trial randomised 17 patients to 100 mg feverfew daily (capsules containing freeze-dried leaves) or placebo for 24 weeks. All patients had taken raw feverfew leaves every day for three to four years. There was a significant increase in attack frequency in the placebo group (p<0.02), attack frequency remained constant in the feverfew group. Five of eight patients in the feverfew group reported good to excellent effectiveness based on a global assessment of treatment, compared with one of nine in placebo group. There are too few patients to draw meaningful conclusions from these results.

    One trial randomised 72 patients to either one capsule dried feverfew leaves daily (dose not stated) or placebo for eight months (crossing over to other treatment after four months). A significant reduction in headache frequency (p<0.005) was reported by the feverfew group compared with placebo. Global assessment of treatment showed feverfew significantly better than placebo (p<0.0001).

    One trial randomised 50 patients with IHS definition of migraine to 143 mg feverfew daily (capsule containing an alcoholic extract of feverfew) or placebo for four months (cross over at two months). There was no significant difference in headache frequency or number of workdays lost between the groups.

    One trial randomised 57 patients with medical diagnosis of migraine to 100 mg feverfew daily or placebo for two months (cross over after one month). All patients had received 100 mg feverfew daily for two month run-in period. There was a significant difference in all outcomes including migraine severity between feverfew and placebo (p<0.01).

    Adverse effects were reported as being mild and reversible. In total three patients withdrew on feverfew and five on placebo.

    Further reading
    Pittler MH, Vogler BK and Ernst E. Feverfew for preventing migraine. Cochrane review 2000

  2. Emily B Says:

    Imitrex works well to treat migraines or a Verapamil is a good drug to help prevent migraines in the first place.

  3. Rebecca S Says:

    YES, thank god. For me at least. I guess it probably depends on the person and the type of migraine they get.

    I take Butalbitol, which is a generic version of Fiorinal (don’t think I spelled that right, sorry). I get migraines associated with my menstral cycle, and if I catch it when it’s just starting (I start with light and sound sensitivity), it will usually go away almost completely. If I wait too long then I’m stuck with it until it decides to leave.

    You can get Butalbitol by prescription, with or without codeine.

    And by the way, I tried Feverfew as a daily supplement, as a tea, and on an “as-needed” basis. I never noticed any relief.

  4. roxy Says:

    I use Imetrex. 100 mg. I’m suffering almost daily now so I need something thats going to work!

  5. deadmeatuk2 Says:

    My wife has a prescription drug called ‘Zomig’ which is the only thing that works for her. However when I get migraines, 3 paracetomol do the trick + dark room.

  6. tiuliucci Says:

    My wife takes Topomax and it helps reduce the number of headaches.

    She takes Zomig when she starts getting a migraine.

    Take care,

  7. gza170382800 Says:

    most of them work if you take them in the early stage of the migraine.

    but the best thing to do is to avoid or be prepared for the things that cause them (certain foods/other physical causes such as long distance driving, etc…)

  8. jdc Says:

    I’ve suffered from Migrains since I was a child. If you don’t want to go the prescription route, Exedrin is the one pill I’ve taken that can actually make my headaches go away, in about an hour.

    Nothing else has ever done that without sleeping it off too.

  9. LadyLynn Says:

    Topomax, Imitrex, Fioricet (Fiorinal,)Midrin, Maxalt, Relpax, Zomig, Frova, Acular, Axert, Anaprox, Orudis, and Sedapep.

    Don’t give up! Every body is different. Try each one until you find the one that works for you.

    My Mom had to try SEVEN anti-depressants until she found the one that worked like a miracle.

    Good luck to you, Sweetie. :)

  10. Dr Frank Says:

    Depends whether you are talking about migraine relievers or preventatives. The answer to both is yes, but none of the drugs are 100%.

    The most effective 2 preventers are probably Sanomigran and propanolol. These are only used in patients who have a minimum of 1-2 attacks per week.

    In terms of treatment there is little to choose between the 5HT agonists, but the oldest, Imigran, is a bit slow to act orally it it very rapid by injection or nasal spray.

  11. US_DR_JD Says:

    There are numerous medications which have proved to be effective in migraine management. However, migraine management in itself is not a matter of taking a single pill. It like many other chronic diseases must be managed with lifestyle changes, prevention, and treatment of acute phases. This may be done with traditional medications, nutritional supplements, herbal remedies, dietary restrictions, accupuncture, psychotherapy, biofeedback and possibly chiropractic manipulation.

    Proper management starts with appropriate diagnosis. In one study less than 65 % of patients were diagnosed properly using IHS (international headache society) guidelines. Another study found significant inconsistency in diagnostic criteria use even among equally trained headache specialist. This has lead to further educational efforts for both headache specialist and GPs alike. Most headache suffeers are not diagnosed with migraines due to the GPs lack of wanting to “label” their patients with the condition.

    The National Headache Foundation produces a lot of literature for the patient and health care provider alike and can be helpful. Go to:

    click on the patient tabs

    then on education resources.

    Print and fill out the headache diary.
    also read the section on “How to talk to your headache doctor” with this guidance you may get a better diagnosis. Also I would suggest you look at the Headache dietary list and the information on rebound headaches.

    There is no one sure answer for which medication is best.

    I rarely if ever disagree with Dr. Frank but I feel propranolol is a poor preventive as well as verapamil. These are designed for hypertension and prevent headahces as a side effect. The other side effects can make them difficult to take.

    Better preventive medications, though also with some side effect problems of their own are the AED or neuro modulators. Zonisamide and Topiramate are the best but Depakote ER has a long track record of success.

    For migrainre relief the triptan medications are usually best, though there are a couple of conditions which can be made worse by taking triptans, so they should not be borrowed and only taken with a presciption.

    Regardless, every patient is different, and it may take a few tries to find the perfect medication for your condition.

    Two important and key points to remember.
    1. Nobody can guarantee 100% cure rates, if they say this, it is a lie and you should ignore them.

    2. See your GP, if you are not getting better ask for referral to a neurologist or headache specialist. DO not seek help by other providers until cleared by your doctors, they may do more harm than good. A good headache specialist will know how to guide your use of alternative medication techniques to your best advantage.

    Having had migraines, I wish you well.

    I now completely control mine with a preventive and biofeedback. There is a therapy for everyone. They take some effort but it will be controlled if you work with your providers

  12. dbgyog Says:

    There is no medicine for H/A OR MIGRAINE. Not only these but for almost all painful diseases. Hence they become chronic.
    Acidity, WORRY, sadness, excessive wind, cold , heat, sour food and sinusitis, constipation, intestinal inflammation; drug side effects, stress, bad smell, TV & COMPUTER SOMETIMES,
    Blockage in the flow of Vital Energy are their causes. None of them can be treated with medicine. Our 100% success in treating migraine &H/A confirms it.

    Acupuncture is the best treatment.
    I can treat it with naturopathy and YOG, but how can you manage pl see.

    Pain killers don’t treat the pain but we loose the sense of pain for some time; in that duration our body itself treats sometime and credit goes to meds.
    The useless drugs have tremendous power of side effects.
    Avoid late sleeping if possible; worry, spicy foods, sour fruits, stale bakery foods and alcohole.
    Sweet foods, COCOANUT WATER,sweet fruits, milk, rice, SPROUTS, SALADS and good sleep will help if cough is not there.

    But you try one herbal remedy- two drops of drumstick leaves’ juice in opposite nostril if one side pains and both nostrils if full H/A will give you rescue. Betel leaf helps but it is very strong.

    If it is acute pl search a painful point 3-6 mm behind your thumb nail and press it, H/A will disappear within 30 seconds.

    It may disappear naturally too.

    R.H. 19, Jhulelal Society, Sector 2/E, Airoli, Navi Mumbai, INDIA.

  13. Kirill K Says:

    Ask your doctor about Imitrex. It’s traditionaly used for migraine treatment.
    Good luck!